Sentence examples for mutation carriers however from inspiring English sources
It is commonly thought that overall life expectancy is reduced among BRCA mutation carriers; however, no accurate estimates of this reduction exist, and the contributing cause is thought to be mainly breast and ovarian cancer [14], [15].
Prophylactic total gastrectomy has been recommended for CDH1 mutation carriers; however, the published data are still limited.
Given a potentially weak and specific effect among BRCA2 mutation carriers, however, analyses in a larger series may be warranted.
Because of the previously described study limitations and because currently there are no definitive international baseline mutation specific estimates of penetrance for risk of breast cancer among BRCA1/2 mutation carriers, however, this estimate should be interpreted with caution.
Our observations support the feasibility of lung transplantation in telomerase mutation carriers; however, severe post-transplant complications reflecting the syndromic nature of their disease appear to occur at higher rates.
Consistent with sporadic breast cancer, menopausal status is a potentially modifying factor in the relationship between obesity and breast cancer risk in BRCA mutation carriers, however results are conflicting.
The lifetime risk of developing breast cancer is drastically increased in women with a harmful mutation in BRCA1 or BRCA2 compared to non-mutation carriers, however a clear prediction with regard to cancer occurrence remains impossible.
The risk of ovarian cancer among the mutation carriers was, however, strongly elevated.
In a recent meta-analysis by Valachis et al., no significant difference in LR after BCT was seen between BRCA1/2 mutation carriers and controls; however, a significant difference was observed when the analysis was restricted to studies with a median follow-up of ≥7 years [ 17].
However, their effects among BRCA1 and BRCA2 mutation carriers is still under debate.
However, the power for the group of BRCA2 mutation carriers is still low.
