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This process should slow the emergence of genetic resistance, because mutation cannot occur if there are no live target bacteria.
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The process stops when the last branch is stopped by a mutation (which cannot occur further back in the past than time t0, the time when the adaptive allele first arose in the population).
In their case, evolution becomes contingent under an adaptive selection pressure because the permissive mutations are neutral by themselves, but without fixation of these permissive mutations, functional adaptation cannot occur.
The existence of this selection pressure operating independently of DNA methylation induced mutation is supported by our finding of mutational biases against CpG dinucleotides among RNA viruses in which conventional deamination and mutation as a consequence of methylation cannot occur.
It cannot occur.
By definition, this condition cannot occur.
Thus, this case cannot occur.
Thus, the case cannot occur.
Hence, Case (a) cannot occur.
So this case cannot occur.
So, Case 2 cannot occur.
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