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The mutation may be tiny, but because the gene is involved in such a complex, multilayered control network, the tiny mutation can trigger a "cascading failure"—a kind of domino effect that leads to a major threat such as cancer or autoimmune disease.
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Mutations can trigger this abnormal folding in rare, inherited diseases.
Like many genetic diseases, a host of different mutations can trigger the condition, and median life expectancy for patients hovers in the late 30s.
Left unchecked, such damage can lead to genetic mutations that can trigger cancer.
A genetic mutation can sometimes trigger the lack of insulin's synthesis, but autoimmune disorders can also trigger the destruction of the islet cells that are responsible for its synthesis.
More surprisingly, the bZIP1 mutation can also trigger N and/or L regulation of genes that are not normally controlled by these signals in WT plants.
These compounds are potential carcinogenic compounds that can trigger mutation within the cells of the body.
These results strongly support the view that, even in non dividing cells, mismatch repair can trigger mutations at distance from the initial mismatch.
5 It is conceivable that CDKN1C mutations in IMAGe patients can trigger an excess of inhibition of growth and differentiation.
Even if this hypothesis were true, a different question is how functionally different mutations in lamin A/C can trigger the same molecular consequence.
Beside many possibilities that may lead to HCC development, it has been shown that accumulation of genetic abnormalities such as chromosomal alterations and gene amplifications, mutations along epigenetic alterations can trigger HCC development [ 24].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com