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Mutagenesis in exchange of a protein activated by cAMP (EPAC) showed that a single mutation can shift the conformational dynamics toward the extended active conformation.
However, an indel mutation can shift a residue's position in one sequence relative to another, whereas the small number of possible states (4 for nucleic acid sequences, 20 for amino acids) can produce spurious matches between residues derived from different positions.
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Since simple mutations in opsins can shift visual capability, the long-term persistence of UV vision suggests an adaptive value to this trait.
Fukui and colleagues identified a mutation in mouse UNC93B1 that can shift its binding away from TLR9 to binding TLR7, which in turn leads to lethal inflammation and development of an SLE-like disease [ 18].
"Like beads on a necklace, we can shift from one to the next in order to anticipate mutations".
Transposition events can shift, replicate, or delete copies of ISs within a genome, which may induce mutations that change fitness of the host cell [ 3, 6, 7].
Momentum can shift quickly, unexpectedly.
Any data point can shift a landscape".
Justices' views can shift over time.
That whole thing can shift rather quickly".
The balance can shift.
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