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Secondly, it is revealed that site directed mutation can inhibit amyloid fibril formation.
Introduction of wild-type PTEN into endometrial cancer cells harbouring PTEN mutation can inhibit cell growth (Lilja et al, 2001).
A gene perturbation, such as knock-out or DNA mutation, can inhibit one or several reactions in a metabolic system.
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Although p53 is often mutated in sebaceous carcinoma (Kiyosaki et al., 2010), many of these transcriptionally inactive mutations can inhibit AR activity (Nesslinger et al., 2003).
Bantam miRNA has been shown to inhibit Hid expression (Brennecke et al., 2003), lending an explanation as to why cic mutations can inhibit the ectopic cell death in rbf1 mutant eye discs.
Mutations in thermosensory neurons have been shown to shorten lifespan even further in warmer temperatures by causing a fall in the expression levels of daf- 9. DAF-9 regulates the nuclear hormone receptor DAF-12 and so daf- 12 null mutations can inhibit this process (Lee and Kenyon 2009).
Mutations in apoB can inhibit binding to LDLR, thereby causing elevated LDL-C levels in the blood [ 13].
IDH mutant proteins can inhibit TET2 activity.
We also mutated F1081 in the FABD helix-3 to glutamic acid in BCR63-ABL because this single substitution mutation can also inhibit F-actin binding [38].
Previous work has demonstrated the importance of domains 1 and 3a of Munc18-1 in closed-conformation syntaxin binding [9] and specific point mutations in domain 1 can inhibit syntaxin binding [11], [29], [30].
We previously reported the effects of single point mutations in mGlu5 which can inhibit the responses of mGlu5 to specific PAMs and NAMs (8, 14, 20).
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