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An mtDNA mutation can inherit maternally or arise sporadically.
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Therefore, whereas females can inherit MECP2 mutations from either parent, male inheritance of MECP2 mutations is exclusively maternal.
In a HuffPost Live conversation on Wednesday, Dr. Mark David Pearlman explained that because both men and women can inherit mutations in certain genes, both sexes can be diagnosed with breast cancer.
Men in families with hereditary breast/ovarian cancer (HBOC) can inherit a BRCA1/2 mutation and pass it on to their daughters and sons.
As most of these mutations will be of rare frequency, one offspring cell can inherit few of them only.
The mutations can be inherited from the parents or they can arise spontaneously in the fetus.
Nuclear-encoded mutations can be inherited in a Men-delian fashion.
26 BRAF gene mutations can be inherited or arise later as an acquired oncogene.
These mutations can be inherited (constitutional) or acquired (somatic) and show a particularly poor genotype-phenotype correlation.
Mutations can be inherited from parents (germline mutations) or acquired over the life of an individual (somatic mutations), the latter being the principal driver of human diseases like cancer.
These results provide evidence that COL4A1 mutations can cause inherited CMD spectrum disorders in a dominant manner, and shed light on the role of this basement membrane protein in normal and disease physiology.
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