Sentence examples for mutation can impair from inspiring English sources
LIS1 (PAFAH1B1) mutation can impair neuronal migration, causing lissencephaly in humans.
For instance, this mutation can impair antigen processing from viral proteins, as well as the presentation of CD8+ T-cell epitope [ 20].
We did not expect TRIM5αhu7KR to restrict infection when expressed in cells because TRIM5αhu residues Lys367 and Lys368 are located in the surface-exposed PRYSPRY loop 5 (Supplementary Fig S8E) (Biris et al, 2012), and their simultaneous mutation can impair restriction activity by decreasing binding to N-MLV capsid protein (Sebastian et al, 2009).
Our results define a novel role for TRiC in mediating oligomerization and suggest that inactivating mutations can impair polypeptide function by interfering with chaperone-mediated folding.
Although acetazolamide increases wild-type chloride currents in vitro, ClC-1 mutations can impair such effect and may limit its clinical efficiency, especially in recessive carriers.
In cardiomyocytes, BAG3 protein localizes at the Z-disc and interacts with the actin capping protein, CapZ β1, stabilizing myofibril structure; BAG3 mutations can impair the Z-disc assembly and increase the sensitivity to stress-induced apoptosis.
The basis for the emergence of resistance with rilpivirine seems to be that both the M184V and M184I mutations can impair HIV replicative fitness, 17 with M184I usually arising first, because it derives from a G to A (ATG to ATA) hypermutation.
This may be due to the K65R mutation that can impair replicative fitness of the virus [ 28].
The genes are then free to accumulate mutations which can impair their function(s), and the unnecessary structures may degenerate.
LBP is an acute-phase protein that initiates an immune response after recognition of bacterial LPS, and mutations in LBP can impair innate immunity [ 60].
It appears that spontaneously occurring human mutations in MUSK can impair signal transduction and synaptic differentiation by more than one mechanism.
