We iterate this procedure until no more rare mutation can be added into mutational event under the certain significance threshold for pathway level gene expression difference.
Although somatic mutation can be a chance event in any body cell, it occurs regularly in the DNA that codes for antigen receptors in lymphocytes.
In the rest of the genome, a gene damaged by a mutation can be swapped out for the good copy on the other chromosome.
The mitochondrial DNA test is less expensive and so sensitive that a mutation can be picked up from a much smaller sample of blood.
The details of multipoint crossover and multipoint mutation can be found in Liu et al. (1996).
Following patient and family member interview and counselling, genetic mutation can be determined from a peripheral blood sample.
The rate of mutation can be enhanced by the addition of chemicals called mutagens or by radiation.
The p53 gene can be detected down to 1 pM, and point mutation can be easily discriminated.
No imaging differences can be found between patients with or without ABCB4 mutation and no specific mutation can be associated with the different presentations [12, 14].
In this way, the distribution and diversity of solutions in the set-based individual after mutation can be guaranteed to a large extent.
In addition, a non-functional aR210Q mutation can be rescued by an aQ252R substitution in TM5 of the a-subunit (Valiyaveetil and Fillingame, 1997).
