Combining these ultra-rare mutations by applying multiple exon skipping is therefore attractive.
The pTrcMscSYFF construct, with mutations W16Y, W240F, and W251F, was used as a template to introduce tryptophan mutations by applying the Stratagene QuikChange protocol.
For 15 of the 20 QTL regions analysed, we were able to strongly reduce the number of candidate mutations by applying concordance analysis.
We analyzed mutation data by applying MutSigCV v.1.4.
In dynamic differential evolution (DDE), after generating the initial population, the candidate solutions are refined by applying mutation, crossover, and selection, iteratively.
The paper proposes a method for locating design errors at the source-level of Register-Transfer Level (RTL) hardware description language code using the design representation of High-Level Decision Diagram (HLDD) models and correcting them by applying mutation operators.
By contrast, genetic algorithms usually encode solutions in strings of discrete bits, and generate new solutions by applying mutation and recombination on multiple existing solutions.
However, by applying mutation rates to phylogenies constructed from Holocene moa, it has been suggested that the last common ancestor of Holocene moa lived 5.8-18.5 mya [ 25, 26].
After the evaluation step, reproduction procedures generate child solutions by applying mutations and a crossover to a parent population.
To date, among 58 clinically well-defined Slovak HNPCC families, 21 clearly pathogenic MMR gene mutations have been identified by applying direct DNA genomic sequencing [ 30, 31].
