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This phenomenon suggests that the cellobiose response of PC-3-7 is affected not only by the bgl2 mutation but also by another mutated gene(s), because there are at least 45 mutations that caused a change in amino acid sequence in the PC-3-7 genome.
Next generation sequencing of target DNA sequences (reads) not only allows to identify a mutation but also gives the percentage of mutated amplicons in the sample analyzed.
The final analyses can correctly identify not only MSTN as the likely causal mutation, but also the regulatory molecules to which it is communicating when mutated.
Higher levels of DNA damage not only cause increased mutation, but also cause increased epimutation.
I often tell people I underwent a prophylactic double mastectomy not just because I had a BRCA2 mutation, but also because my medical team analyzed my specific mutation ― as well as my family history of early-onset breast cancer ― and determined surgery was the best risk-reduction strategy for my particular situation.
Interestingly, the manifestation of the disease does not solely depend on the mutation, but also on environmental factors.
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Not only is genetic variation important in determining the fate of individual beneficial mutations, but also this variation itself fluctuates according to the stochastic nature of mutational events.
The biomarketer must constantly research the environment and the vagaries of each population, looking not only for the gradual mutations but also for the bursts of change.
3) Development of both diseases not only depends on T or B cell intrinsic factors, such as germline or somatic mutations, but also on environmental factors.
Recently, we have created doubly transgenic mice carrying not only the lambda shuttle vector for reporting mutations but also a targeted disruption of the mouse PMS2 gene, a homolog of the E. coli mutL gene involved in mismatch repair.
In recent years, geneticists have been searching for causes of disease not just by seeking out people who carry mutations, but also those who lack a working copy of a particular gene.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com