Sentence examples for mutation bound to from inspiring English sources

In contrast, HA with the G228S single mutation bound to both ciliated cells and non-ciliated cells (Figure 4G).

Here, we determined the first crystal structures of the human FGFR4 kinase domain (FGFR4K) alone and complexed with ponatinib, a promiscuous type-2 (DFG-out) kinase inhibitor, and an oncogenic FGFR4K harboring the V550L gate-keeper mutation bound to FIIN-2, a new type-1 irreversible inhibitor.

We wanted to examine how our Y1065 mutations bound to Vh by performing head tail pulldowns with GST-tagged Vh (contains D1 D4; residues 1 811) and evaluated differences in head tail interactions.

The HA mutant bearing G228S in combination with the Q226L mutation also bound to both ciliated and non-ciliated cells (Figure 3I and 3J) indicating a partial switch in cell tropism.

At the same time, this mutation was actually quite predictable and is obviously required: when science and technology concern all aspects of life in society, the way we are educated and the way we work, commute, communicate, and even reproduce, a major mutation is bound to take place.

Molecular evolution that is determined by trade-off and sign-epistasis [ 8] effects may be expected to be constrained to follow a few mutational paths (as mutations are bound to occur in a rather specific temporal order to avoid deleterious intermediate combinations).

Further screening showed that β-arrestin1 8M, a β-arrestin1 point mutant harboring the R282A, E283A, K284A and R285A mutations, weakly bound to either APH1-AL or APH1-B and had little effect on the γ-secretase activity.

In this situation, the Y degenerates because it recurrently looses the class of least-loaded Y chromosomes (Muller's ratchet) or because the classes of Y chromosomes with deleterious mutations are bound to disappear and thus reduce the effective population size (background selection).

Whereas the last 55 residues of the C-terminal PEST domain are required for the interaction of PTPN18-WT with HER2, the catalytic domain (CD) with the inactive C229S mutation also binds to HER2.

Furthermore, via examination of the effect of the D2-K317R mutheinteractionteractiof of the NO3– bound to the Cl-1 site can be specifically studied.

Does the high prevalence of mosaicism in our tissues mean that it is impossible to recognize and eliminate cells with subtle mutations and that suboptimal cells are bound to accumulate within organs?