Sentence examples for mutation both of from inspiring English sources

Chicken B cell line DT40 continuously accumulates mutations in the immunoglobulin variable region (IgV) gene by gene conversion and point mutation, both of which are mediated by activation-induced cytidine deaminase (AID), thereby producing an antibody (Ab) library that is useful for screening monoclonal Abs (mAbs) in vitro.

MDA-MB-231 cells also harbor a KRAS mutation and a BRAF mutation, both of which could further activate the MAPK pathway.

Still, for this double mutant and the single downstream branch point mutation (both of which are unable to produce a lariat precursor), circular RNA production is slightly higher than predicted under a model relying exclusively on a lariat.

Testing for the A1555G mutation (associated with aminoglycoside-induced hearing loss) and the A7445G mutation, both of which are associated with some rare familial cases of hearing loss, may be appropriate after common GJB2 mutations are excluded.

Furthermore, we have provided strong genetic evidence that Rab2A is abnormally activated in human cancer by either gene amplification or activating Rab2A point mutation, both of which enhance its ability to activate Erk1/2 signaling.

However, caution is necessary when extrapolating these findings to ALS, because individuals with (heterozygous) mutations in TARDBP possess a wild-type copy of TARDBP in addition to the allele containing a missense mutation, both of which are expressed throughout the progression of this disease.

Furthermore, two of the mutations studied were on the C57BL/6J background with the Aw-j or Tabby mutations, both of which affect coat color.

Recurrent and novel mutations, both of which are rare, were first described in CHRNA4 for autosomal dominant frontal lobe epilepsy.

Sequencing of all 16 coding exons of the AAAS gene revealed compound heterozygosity for two mutations, both of which are predicted to premature stops in translation.

None of the animals carried the known myostatin or callipyge mutations, both of which result in enhanced muscling (results not shown).

Mutation of both copies of Establishment of Sister chromatid Cohesion acetyltransferase 2 (EScausesauses RBS (3).