Sentence examples for mutation blocked the from inspiring English sources

Whereas, tyra-2 mutation blocked the AIMs calcium reduction in response to tyramine (Fig. 3B, C, D).

Recycling only occurred in vps37Δ cells, as the mutation blocked the entry of Fur4-GFP into the vacuolar lumen; in wildtype cells all Fur4-GFP was targeted to vacuolar lumen, where it was degraded [12].

Similarly, the 4D mutation blocked the effects of wild-type PTEN.

The F32E mutation blocked the binding of the isolated PRH N-terminal domain to TLE in pulldown experiments.

Functional analysis revealed that this E682K mutation blocked the β′-site and shifted cleavage of APP to the β-site, causing increased Aβ production.

In agreement with the results obtained from analyzing the CTF levels, the E682K mutation blocked the generation of the Aβ11 40/42 peptide while it enhanced generation of Aβ1 40/42 peptide (Fig 3D).

The E682K mutation blocked this processing step and consequentially shifted BACE1 cleavage towards the β-site.

Krox-20 null mice or hypomorphic mutations block the myelination program at the premyelinating stage [21], [22].

These mutations block the maturation of late endosomes to lysosomes at different levels, similarly causing signaling receptor accumulation.

Indeed, the variants M1775R and M1775K fall into this class, and previous structural and peptide binding studies revealed that conformational changes associated with these mutations block the +3 specificity pocket of this surface.

Pollock et al. (2003) demonstrate that ppIL-1α interacts with various RNA splicing proteins, and that a point mutation blocking this interaction inhibits the pro-apoptotic effects of ppIL-1α.