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If mutation bias variation patterns do occur, they should affect all base positions within the gene, including coding and non-coding sequences.
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It appears that variation in GC mutational bias explains over 60% of the variation of the codon usage bias.
Likewise, the variation in nucleotide content found among chelicerate mitochondrial genomes on the major coding strand either must be due to natural selection affecting which mutations becomes substituted, or must reflect neutral substitutions governed by mutational bias.
The width of the GC3 distribution in flowering plants was found to be a result of variation in the levels of directional mutation pressure or selection against mutational biases.
All models perform relatively well in terms of relative bias and variation of relative bias.
Our results suggest that CUPrefs in HPVs reflect either variations in the mutation bias or differential selection pressures depending on the clinical presentation and expression timing.
Mutation may drive variation in nucleotide content, if different bacterial lineages vary in their mutational biases.
These authors argued that the variations in the AA compositions among species were caused by nucleotide mutation bias.
Both Nc plot and correspondence analysis on relative synonymous codon usage indicates that mutation bias influences codon usage variation in the 16 phages.
In addition to being a major source of variation, mutation may also function as a mechanism of evolution when there are different probabilities at the molecular level for different mutations to occur, a process known as mutation bias.
Mutation bias effects are superimposed on other processes.
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