Sentence examples for mutation becomes lethal from inspiring English sources
This is not always the case in micro-organisms such as E. coli where the dut1-1 mutation becomes lethal when accompanied by either recA(Ts) or recB(Ts) mutations when grown at non-permissive temperature [11].
Co-lethality, or synthetic lethality is the documented genetic situation where two, separately non-lethal mutations, become lethal when combined in one genome.
For example, a mutation that increases the distance to the optimal phenotype by 0.1 units may decrease fitness by 10% in the optimal genotype (which by definition has a fitness of 1); an analogous mutation will decrease fitness by 50% in an organism with a fitness of 0.2; this mutation will become lethal in any genotype with a fitness less than 0.1.
However, when levels of functional Smc dimers are in addition reduced for example by hypomorphic mutations in the smc gene itself, the loss of ParB protein becomes lethal (Gruber and Errington, 2009).
A dose that would previously have been acceptable becomes lethal.
Plus, the GS4 touts 2GB of RAM, which becomes lethal combined with the Snapdragon 600.
Breast cancer becomes lethal when visceral metastases develop.
Synthetic lethality occurs when two lesions that are individually non-lethal become lethal when combined.
To explain why humanity still exists, the researchers suppose that harmful mutations tend to become lethal--and are weeded out--only when they occur in bunches.
The growing smoke soon became lethal.
