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23 The increase in heteroplasmy level is through a process of clonal expansion whereby 1 mutation becomes dominant within the cell.
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Homoplasmic mutations have also been confirmed to occur in cancerous lesions, indicating that mutant mtDNA becomes dominant in tumor cells [25], [26].
In the course of several replications the heteroplasmic mutation may become dominant leading to cancer [ 8].
This finding raises strong concerns that the H275Y mutation could become dominant in pandemic (H1N1) 2009 as well.
For instance, both C and H are under-estimated and the residues of these two amino acids in proteins may be negatively selected when mutation drives become dominant to convert them to R and Y, for instance.
But gradually an overall impression becomes dominant.
That genetic disposition becomes dominant over time.
In general, the most likely correlate of the ability of a resistance mutation to survive and become dominant in a newly-infected host is if such a mutation does not have a significant impact on viral replicative capacity.
The observation that most mtDNA mutations found in UC patients were homoplasmic in nature indicates that the mutated mtDNA had become dominant in the colorectal mucosa of UC individuals.
Earl and Deem found that larger mutational shifts (recombination/swapping rather than point mutations) were selected for, and became dominant, when landscape shifts occurred faster and/or were larger.
The population with two mutations required eight weeks to become dominant.
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