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The differences are less extreme when considering the probability that a newly arising mutation becomes common in the population because the fate of new mutants is determined largely by drift while they remain rare.
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One such mutation became common in Europe and North India, another among the tall cattle-herding peoples of east Africa.
It seemed that natural selection has weeded out any disease-causing mutation before it becomes common.
When assayed, the mutation and the marker always appear together in the population, and over time the haplotype carrying the mutation can become common.
One way a seemingly deleterious mutation can become common over time in a group of people is if it also has a benefit that outweighs its harm, explains co-author Douglas Bell, a molecular biologist at the National Institute of Environmental Health Sciences in Research Triangle Park, North Carolina.
With the recent development and testing of new promising targeted therapies for patients with metastatic melanoma, 139 141 molecular pathology mutation testing for BRAF, NRAS, KIT, and other mutations has become common in many melanoma treatment centers.
Bedwetting becomes common.
The contribution of known genes is higher than this in certain populations where specific BRCA1 or BRCA2 mutations have become common as a result of founder effects.
It seems like an extremely prescient twist of genetic fate: A mutation that confers HIV resistance became common in Europe centuries before the AIDS epidemic.
But not every person with the mutation becomes ill, they said.
FQ-resistance mutations in S. Typhi have become common, hindering treatment and control efforts.
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