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Under both viability and maternal selection, the conditions for successful invasion of a new mutation become very restrictive as mean fitness increases and fewer alleles can invade.
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In that year the allelic frequency of the disease in the cow population increased sharply because some sires that had been carriers of the mutation had become very popular 2 4 years before.
Mice carrying the Ins2Akita mutation become hyperglycemic very early in life, however, no differences could be observed in conditions of A20 deficiency in β cells.
With this in mind, some of the XRCC4 mutations reported in humans become very interesting as they affect residues localized in the head domain, the region of interaction with Cernunnos/XLF.
These scattered sequencing mistakes become very problematic when studying mutations present in <1% of cells [ 46].
"I've become very, very disciplined.
You suddenly become very brave.
It's become very competitive.
"His responses become very brief.
We become very self-conscious.
"We have become very friendly.
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