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As a result, the mutation became more prevalent over time.
When the mutation was associated with a mitochondrial genome that had a strong drive towards replication, the mutation became more widespread over time, and in most cases, this eventually resulted in the mutation killing the flies.
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Supplementary Figure 1 Hypha that were induced by the chk1-hyp mutation become more resistant to washing when grown on EMM-2 agar media.
The similarity increases with age which is most likely to indicate a convergent gene expression phenotype in the striata of these models as the effects of the mutation become more marked and overcome differences between the models.
As μ increases, mutations become more abundant, and changes of fitness upon replication increase in frequency.
Since duplicate domains and duplicate genes provide two possible layers of functional redundancy, the interpretation of mutations becomes more complex.
In particular, we found that, although DNMT3A R882 and JAK2 V617F mutations become more common with age, they were also found in younger individuals.
The particular value of the effective strength of selection at which the rate of evolution is at its maximum increases as mutations become more biased.
As testing for BRCA1/2 gene mutations becomes more widely available as a clinical service, increasing numbers of women are being identified at high risk for breast and ovarian cancer.
Due to mutation, the structure became more rigid which is also supported by NH bond, density plot, PCA, and DSSP analysis.
On the other hand, flexibility analysis using dynamic quenching and limited proteolysis demonstrates that D474K mutation became much more flexible than wild type although D476N doesn't have any significant difference.
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