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Using the Pfam-A seed profiles of each domain, we obtained these observables for all variant sequences that are one missense mutation away from the reference, i.e., mutational opportunity ℳ.
At one point you say that busking is only "a minute chromosomal mutation" away from skateboarding.
However, H46b and H88 haplogroups are only one-step mutation away from the extant ancestral haplogroups (H46 and H*, respectively).
Sabouri, Z. et al. Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity.
But he did note a slight mutation away from the Powell approach: When air campaigns can be conducted with no American casualties and no American ground troops, there is "another generation of thinking that is not inconsistent with the doctrine of using overwhelming force -- and that is using force for more limited purposes but in a way that gives us overwhelming advantage," Mr. Berger said.
In our study, 78% (43/55) of the pre-XDR isolates were resistant to a fluoroquinolone and were, therefore, one mutation away from becoming XDR.
Similar(39)
Mutations toward the consensus generally resulted in an increase in folding stability, whereas mutations away from the consensus resulted in decreased overall stability.
If genetic analysis found a virus somewhere that was only one or two mutations away from going airborne, public health officials would then know to bear down aggressively in that area to limit human contact with infected poultry and ramp up supplies of vaccines and medicines.
The conclusion, says first author Colin Russell of the University of Cambridge, is that a virus that is only three mutations away from the full set is "likely" to acquire them and end up in droplets.
A new paper published this summer forecast the virus being three mutations away from such a reality.
Two of the five mutations have already been found in wild birds -- which means that some avian virsuses are just three mutations away from becoming transmissible between mammals.
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