Sentence examples for mutation augments the from inspiring English sources

Although we cannot formally exclude the possibility that a BRCA1 mutation augments the effect of NBN p.R215W on NBN levels and radiation-induced foci formation, the functional BRCA1 deficiency does not cause these effects as is also evidenced by the observations of normal NBN levels and foci formation in other cell lines such as HCC38 or HCC1806 which are functionally deficient in BRCA1 [ 40, 41].

The most dramatic effect on synthesis was seen after the T1471D mutation (augmenting the negative charge at the regulatory acid stretch, nine amino acids from the C-terminus of wt-CFTR), which abolished the mature 'band C' form of CFTR reminiscent of the findings when F508delCFTR fails to mature in the Golgi from band B (in the ER) to band C (in the plasma membrane).

By contrast, RfBP resembled a peroxisomal catalase mutation, which augments the cytosolic H2O2, to enhance FD and AP1 expression and induce early flowering.

This double mutation therefore augments the stiffness of the linker arm, which is otherwise only partially rigid in M13V (relative to M13V/K22M), as shown by enhanced levels of protection for the double mutant.

Based on our study of different sequence weighting options for HMMs with and without the point mutation augmented training for the task of learning SCOP superfamilies (Kumar and Cowen, 2009) we used SAM sequence entropy (Karplus et al., 1998) throughout the present study.

Bioinformatics approaches to predict the effect of mutations on protein stability utilizes the sequence alignment information of evolutionarily related sequences [51] or protein families or rely on physicochemical modeling of the mutation augmented by information obtained from statistical analyses of protein sequences and three-dimensional structures [52].

Genetic background also influenced the ability of the Gly573 Ser mutation to augment the predilection of mice toward chemically evoked allergic contact dermatitis.

While only target modification confers high-level resistance to quinolone antibiotics, the low-level resistance (less than a 10-fold increase in the minimum inhibitory concentration) conferred by the other mechanisms augments the probability of developing such mutations.

This is of note, because it augments the line of evidence for an association of protein-truncating mutations with a more severe impairment of holo-ceruloplasmin synthesis.

Notably, mutation of ICP6 makes the virus more sensitive to the drugs acyclovir and ganciclovir [32], which augments the safety of the virus as a clinical therapy.

V.R. augments the therapeutic process.