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Of the eight aspartic acid sites, we mutated (residues 753, 771, 780, 781, 815, 836, 841, 849), only the D>N mutation at residue 849 decreased cell death.
In keeping with the importance of this ALK mutation, patients with tumors carrying ALK mutation at residue 1174 were found to have a poor clinical outcome19.
Mutation at residue 162 (R162A) neither enhanced nor impaired the avidity of Envgp120-C3d2 for sCR2 in vitro.
We generated a crRNA and crHyb, which contained a C > A mutation at residue 5 (located in the non-seed region and which showed no sensitivities for encoding as RNA or DNA) and tested for activity on the unmodified DNA template.
This paper analyses, using a panel of well-characterised Mabs, the effects on the antigenicity of various C- and N-terminal deletants of HPV-16 L1 made in insect cells via recombinant baculovirus, of an A → T mutation at residue 266 (and6T), and of a C → G mutation at conserved position 428 (C428G).
A mutation at residue 226 of the membrane fusion glycoprotein E1 E1-A226VV) was detected in more than 90% of Chikungunya virus isolates from Reunion Islands in the 2005 outbreak.
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We have performed site directed mutagenesis to introduce two mutations at residue Thr84, T84A and T84S, to explore the binding affinity of the substrate and the catalytic mechanism.
In contrast, mutations at residue L35 appear to be important for obtaining good (S,S -2 variantS,S -2
We further examined whether the mutations at residue 70 affect susceptibility to NRTIs in the Q151Mc background (Figure 2B and also Table S3).
Reciprocal Cys<->Ser mutations at residue 67 of the native Nv-NF-κB proteins affect DNA binding as in human NF-κB proteins, e.g., a Cys->Ser mutation increases DNA binding of the native Cys variant.
Only patients who had VF (defined as plasma HIV-1 RNA>400 copies/ml after three months on RAL and/or >50 copies/ml after six months on RAL) with selection of mutations at residue 143 were included in this study.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com