Sentence examples for mutation at one from inspiring English sources

It relates to (intragenic) epistasis: the selection coefficient of a mutation at one site depends on the states at other sites.

The functional topology of sequence space depends strongly on the degree and type of epistasis, defined as genetic interactions between sequence sites, such that the effect of a mutation at one site depends on the state at others.

This resistance to APC was first characterized by Dahlbäck and coworkers [ 21] and derives from a mutation at one of the APC inactivation sites (Arg → Gln) on FV/FVa rendering it resistant to APC cleavage [ 22].

No germline mutations could be identified in the breast cancer families and only one sporadic carcinoma carried a PTEN mutation at one allele.

This alteration also reported in gastric cancer as a somatic mutation at one allele, while the other allele had lost[ 7].

A mutation at one position in the protein may, however, have little effect if it is accompanied by a 'compensatory' mutation at another position.

To address this problem, we have extended the K a / K s concept to consider interactions with other sites, by formulating a conditional K a / K s that measures the effects of mutations at one site on the selection pressure for mutations at another site.

That is large mutational many mutations at one locus, that place a population closer to long-term equilibria may be lost because the appropriate trait values at the other locus do not yet exist.

However, the tRNA-Tyr genes do not mutate at equal frequency; mutations at one locus (SUP6-o) represent 31% of the ochre suppressors, whereas two other loci (SUP2-o and SUP8-o), each account for only 2% of the suppressors, suggesting that the rate of GC to TA transversions is nonuniform across the yeast genome (Ito-Harashima et al. 2002).

For example, when we transformed a multiply-mutated fragment into a strain, the frequency of incorporating mutations at one end was approximately was four-fold higher than the frequency of incorporating mutations at the other end.

Mutations at one of the three residues – N155, Q148, or Y143 – resulted in high level resistance.