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For instance, Y chromosomes bearing a specific C→T mutation at locus M242, named as Q, were observed initially in natives of America, Siberia, and Mongolia, an arrangement identified as the ancestral chromosome of Q1a3a (Bortolini et al. 2003; Karafet et al. 2008; Seielstad et al. 2003).
Sequencing of the rpoB gene from this isolate identified a mutation at locus 516 (Asp → Tyr).
All samples were known with IDH1 mutation at locus R132H determined by DNA sequence analysis.
Bivariate analysis of the present work showed that the mutation at locus 168 was overrepresented in the caries-free group and that the mutation at locus 470 was overrepresented in the high-severity caries group.
This result demonstrated that the S. mutans strains with a point mutation at locus 168 in srtA may have a lower risk for high-severity caries.
The probability that the mutation at locus l is present in a fraction f of cells is obtained by fitting a Gaussian mixture model on (Fig. 1A).
Similar(51)
Then, a weakly beneficial mutation occurs at locus A, resulting in a single copy of A1 on the island.
Cloning analysis of the IN gene showed an independent selection of the mutations at loci 155 and 143.
Phylogenetic analyses comprising all clonal sequences for each patient suggested an independent selection of the mutations at loci 143 and 155 (data not shown).
They may include environmental factors, reproductive errors or genetic mutations at loci different from ZFP57.
Nevertheless, mutations at loci involved in GSI but that are unlinked to the S-locus are also observed [ 74, 75].
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