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However, in three B. pseudomallei strains a point mutation at gene position 798 (G to C) disrupted the AvaII site.
The seed genes were then fed into a stepwise correlation-based selector to identify 271 additional features including 177 genes, 82 copy number variation sites, 11 methylation sites and 1 somatic mutation (at gene TP53).
The web interface allows browsing data by gene name, cancer type, sites and projects, reporting the frequencies of mutation at gene and genomic location InOGen also allows the study of genomic alterations in cancer in the contest of pathways [ 65].
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Based on these lines of information, we examined the daughter cells' patterning with a collection of E. coli strains with single mutation at genes linked to bacterial surface structures.
Also, one possible explanation for a global affectation at imprinting loci could be the presence of mutation at genes coding for transacting factors involved in imprinting establishment.
Besides a list of missense mutations at gene and protein sequence levels, GALT-Prot reports the analysis results of mutant GALT structures.
Failure to repair cytidine deamination would result in the accumulation of deleterious mutations at gene enhancers.
For instance, it may be tempting to analyze sE-cad levels in parallel with those of other key molecules or markers and to characterize sE-cad associated with CDH1 mutations at gene level both in vivo and in vitro or to expand knowledge about the candidate molecules triggering cleavage of the full length E-cad into its soluble form.
Two other CAN genes, SMAD2 and SMAD3, also did not have significant mutation frequency at gene level, but did have significant mutation frequency within the MH2 domain contained within each gene.
Moreover, in the D. melanogaster comparison, the polarized MK test (using D. yakuba as the outgroup) revealed a significant excess of fixed nonsynonymous mutations at genes Or65c and Or67a in the D. melanogaster lineage (results not shown).
When I- SceI endonuclease was synthesized in starvation-stressed cells, the resulting DSBs cause a 50 6,000-fold increase in mutations at genes in the DNA molecule with the I- SceI cutsite 11, 12, 250 6,000-fold
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