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An analysis that does not discriminate between BRCA1 and BRCA2 estimates the genetic effect on survival after breast cancer for women carrying a mutation at either site.
We prepared two modified Py23 sequences with one additional C-to-T mutation at either position 13 or 14 to isolate each isomer.
SAMPLEX was run to determine the significant changes in the CSP data of the two binding sites obtained from NMR titrations of Josephin constructs with a mutation at either site 1 (I77K-Q78K) or site 2 (W87K).
Next, we introduced a mutation at either of these two serines.
A single nucleotide mutation at either codon 83 or 87 of the gene encoding the GyrA protein (gyrA) confers resistance to nalidixic acid in S. Typhi [ 17].
Twenty-eight (36%) of the 76 CRC samples examined showed a mutation at either codons 12 or 13 of the K-ras gene.
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Mutations at either Gly2 or Asp26 resulted in recessive loss of function.
However, of all loxP integration events, only 48% in CAR and 33% in POR were products of precise ligation, while the remaining loxP integration events contained mutations at either or both ligation junctions, or deletions within the loxP donor.
Of the six recombinant viruses expressing NA with mutations at either E227 or E276, only the E227D and E276D viruses were able to grow without supplementary NA activity, and all mutant viruses had a significant reduction in NA activity.
Mutations in two codons are rarely found among field isolates of Salmonella while mutations at either Ser83 and or Asp87 are very commonly observed [33].
In this study, we found that the activities of promoters with mutations at either ChoRE or both ChoREs were largely unaffected by siRNAs targeting MondoA or MLX (Figure 5).
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