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Such discrepancy has been attributed to distinct causes, namely: to differences in the rate of mutation at different mtDNA positions; to the effect of selection and genetic drift; to the occurrence of somatic mutations; to the unintended sequencing of nuclear mitochondrial pseudogenes; and to the leakage of paternal mtDNA and recombination.
Open image in new window Fig. 3 Distribution of a set-based individual before and after mutation at different generations.
The core work is to uniform mutation nomenclature, locate mutation at different reference genome, record association between mutation and disease, and integrate meaningful annotation from both text-mined results and other databases.
The "-v" option provides the flexibility to designate different rates of mutation at different loci, and the mechanics of its usage are described in detail in the SFS_CODE manual.
To test the existence of alternative start codons in TMEM16A, we generated several constructs each one carrying a stop codon mutation at different positions within segment a (Fig. 3A).
The rate of mutation at different sites on the ribosome could vary wildly and exaggerate the true distance between the superkingdoms, even if they do represent a very ancient split.
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Of course, fitness advantages will also differ between mutations at different loci, even within the same cancer type.
From the result of mutational analysis (summarized in Table 2), some unique mutations at different geographical locations were found.
The difference in the pattern of non-conservative mutations at different levels of iFLC suggests that non-conservative mutations in key areas of the immunoglobulin light chain may affect the rate of amyloidogenesis of the protein.
However, the guidelines do not address whether truncating mutations at different positions along the length of the protein might differ in phenotype severity or mechanism of action, a finding that could complicate interpretation of truncation mutations for a broad range of inherited diseases.
However, in linked regions of rapidly adapting genomes, multiple beneficial mutations at different loci can segregate simultaneously within the population, an effect known as clonal interference.
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