Sentence examples for mutation at both from inspiring English sources

We also mutated dimeric interface of BmGK and identified intersubunit residues, Arg105 and Glu140, essential for dimer stability as double mutation at both positions hinders dimerization.

In our experimental design, we hoped that gene expression differences between any two individuals would be averaged out, highlighting changes due to this specific mutation at both NPC1 alleles.

Mutation at both phosphorylation sites, serines-305/307/309 and serines-426/430, abolished the effect of ePK-mediated CD98 phosphorylation on cell adhesion, further demonstrating the contribution of phosphorylation to the adhesive function of this molecule.

The escape E is the escape which only carries a mutation at the escape locus and regardless of the type of allele at the compensatory locus; the escape EC is the escape which carries a mutation at both escape locus and the compensatory locus (see Fig. 1C).

For FLT3, also switches of the mutation type at progression of AML (initial diagnosis with D835 tyrosine kinase mutation, relapse with internal tandem duplication) but stable NPM1 mutation at both time points are documented.

To test if the Cy elements were sufficient to account for the p21 requirement in PDGF-induced ODG, we generated additional RCAS constructs containing full-length p21 harboring either a single mutation at the Cy1 or Cy2 site, or a double mutation at both sites.

Moreover, these results indicate that the mutated version containing mutations at both loops 2 and 3 possessed new binding sites for BtR175, which probably resulted from a conformational change in the double mutant.

For the glucose response test, the activities of promoters with mutated ChoRE-a or with double mutations at both ChoREs were not stimulated by glucose; and as compared with the wild type promoter, the response of the ChoRE-b mutant promoter was significantly reduced (Figure 4C and 4D).

The first (IP3RL60E) is mutated at the 8-position of the 1-8-14 1-8-14 1-8-14 second has motifions andbothethe 1- (F53E) and 14-poseconds (Y66E) (IP3RFY).

We observed efficient gene targeting but found that targeted clones carried an unexpectedly high frequency of insertion and deletion (indel) mutations at both alleles of the targeted gene.

Contraction of palindromes would be due to mutations at both ends of palindromes as evident from Gallus sps (Supplementary File S3).