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There was also a novel mutation at a position already found mutated, R479Q.
(4) The relatively high frequency of multiplets with two or more clustered mutations and an additional mutation at a distal location also argues for a chronocoordinate mutational event plus an independent single mutational event.
The researchers found the genetic mutation at a high frequency, which told them that its presence must inhibit a horse's transition from trot to gallop at high speeds.
Results from a preliminary genetic analysis (Tinghitella 2008) are consistent with flatwing being a mutation at a single X-linked gene.
Dozens of studies have suggested that a mutation at a nearby position 627 can make H5N1 avian flu viruses more virulent and more transmissible between humans.
Thus, in many cases the impact of multiple mutations can be calculated by first determining the effects of a mutation at a single position and subsequently summing these effects using the quasi-additive assumption.
We are aware that this does not necessarily imply that OP is caused by a mutation at a single locus.
This screening gave the probability of 0.0005 to have this mutation at a frequency of 0.02 in our population (frequency found in Papua New Guinea).
This is due to the fact that diversification within species is driven by mutation at a rate higher than speciation within lineages.
These observations were similar to a study that observed frameshift mutation at a noncoding (CA 13 microsatellite in an hMLH1−/− background [25].
For example, in response to a mutation at a neighboring site, a residue might switch from varying among one set of amino acids to varying among another set.
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