Sentence examples for mutation at Pfcrt from inspiring English sources

To identify prevalence of chloroquine resistance point mutation at (Pfcrt, K76T) and (Pfmdr1, N86Y) copy number variation.

Parasite 106/1K76 has six mutations found typically in Southeast Asian CQR parasite (compared with 3D7 and other CQS wild type parasites), except a key mutation at PfCRT 76 position [1].

The lysine to threonine mutation at residue 76 (K76T) in pfcrt was present in all chloroquine resistance strains, and the amino acid haplotype of CVMNK was present in chloroquine-sensitive strains (Table 1, Table 2).

Second, CQ-resistant CVMNT haplotype parasites may have arisen by a single point mutation at position 76 in the pfcrt gene among naturally infected persons in Haiti, a mutation that could convert the predominant CQ-susceptible CVMNK haplotype to a CQ-resistant CVMNT haplotype.

Interestingly, they also showed that the introduction of the K76T single mutation in PfCRT of CQS parasites is necessary but not sufficient for the transport of chloroquine via PfCRT.

The higher (or lower) levels of up- or down regulation of the genes could reflect parasite responses to additional change at PfCRT 352K and/or QN selection pressure.

The overall prevalence of the N86Y mutation in pfmdr1 and K76T mutation in pfcrt was 47.0% and 60.2%, respectively.

C67G8 contains an additional I351 M mutation in PfCRT that does not occur in 7G8 parasites [ 18].

A point mutation in the Plasmodium falciparum chloroquine-resistance transporter (PfCRT) gene is responsible for chloroquine-resistant falciparum malaria [ 20], whereas disappearance of the K76T mutation in PfCRT is associated with chloroquine susceptibility [ 21].

In Mali, the K76T mutation in pfcrt was observed in persons with persistent or recurrent infection after chloroquine therapy, indicating selection for this mutation.

Presence of the chloroquine resistance associated K76T mutation of Pfcrt (chloroquine-resistance transporter) (11 ) was analyzed by nested allele specific PCR.