Sentence examples for mutation as they from inspiring English sources

In the case of tetracycline and macrolides, reversions to susceptibility appeared to have occurred through more than one type of mutation, as they were associated with both the presence and absence of the associated resistance gene.

Three cysteine residues in the extracellular regions of TM1 (C601.43), TM4 (C1714.48), and TM5 (C2165.41) were selected for mutation as they were lipid-exposed, and possibly involved in dimeric interfaces involving TM1, TM4, or both TM4 and TM5, as previously demonstrated for D2R (22, 22).

Characterisation of the morphology of breast cancers arising in PALB2 mutation carriers and non-carriers offers the possibility of identifying tumour morphological features predictive of an underlying germline PALB2 mutation, as they have been shown for underlying BRCA1 mutations (Lakhani et al, 1998; Southey et al, 2011; Hopper et al, 2012).

Indeed, we observed that mutations in the master regulator gene ctrA [ ctrA(T170A )] or its antagonist gene sciP [ sciP(T24I ) or sciP T65A )] (Fumeaux et al., 2014) are epistatic to the Δ mucR1/2 mutation, as they conferred near normal P hvyA - hvyA::lacZ translation and a normal cellular buoyancy (capsulation) pattern with 'heavy' and 'light' cells, while P hvyA was still de-repressed.

However, caution may be needed when interpreting the effects of the 15′ mutation as they are conspicuously similar to those of alcohols and channel mutations that enhance ligand efficacy rather than directly affect a specific binding site (Lovinger and White, 1991; Downie et al., 1995; Palma et al., 1996).

In this study, residues forming hydrophobic interactions with the substitution groups on the aporphine scaffold of -crebanine (1) were selected for mutation as well and they are Thr1393.37, Gly2185.42, Ala2225.46, and Leu209ECL2.

By extension, any thrifty mutations, as long as they occurred during the first 97.2% of human history, would already be at complete fixation.

Cells also tend to pick up new mutations as they divide.

After a number of tricks in which the magicians sprout increasingly bizarre mutations as they try to outdo each other, they tear each other limb from limb before their component parts strike an uneasy truce.

Tumors arise from single cells but become genetically heterogeneous through continuous acquisition of somatic mutations as they progress.

It is based on a decreasing law for the generation of beneficial mutations as they become fixed in the genomes.