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"Are they as proven as David Wright?
Currently, in the Netherlands, 50% risk carriers of heritable cancer syndromes who choose not to know their genetic status have access to the same screening programmes as proven mutation carriers.
Thus, the p.Asp24Val mutation was proven to be deleterious.
As the index patient is homozygous for the mutation, no full-length DSP-1 could be produced as proved by western blot analysis (Fig. 6).
Moreover, the mother gene mutation carriage was proven.
The previous bmr mutations have proven to be useful in improving the digestibility of sorghum plants as forage [ 47].
Moreover, the identification of underlying mutations has proven difficult.
Consensus mutations have proven effective for increasing stability, but these mutations are successful only about half the time.
However, as the csn1Δ mutatione1-50 mutation proved to be lethal, we used HU to inhibit dNTP synthesis instead deleting csn1 +.
The classification of several splice-site variants as true pathogenic mutations may prove useful for genetic counselling of families with high risk of breast and ovarian cancer.
Thus, ubp1 mutations may prove to play a role in multi-drug resistance, as is the case for mdr1 [ 43].
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