The assay was used to analyze 311 blind cultured sputum-positive tuberculosis samples, among which 137 were detected to harbor 23 different types of mutations, as confirmed by DNA sequencing of PCR amplicons (Table S4).
The assay was used to analyze blind serum specimens from 165 patients including 99 treated patients and 66 untreated patients, among which 49.5% and 4.6% were detected to harbor lamivudine- and/or adefovir-resistant mutation(s), respectively, as confirmed by DNA sequencing of PCR amplicons (Table S5).
Our data show that K187 in histone H1.2 is a new target of HKMTs G9a and its interaction partner Glp1 in vitro and in vivo, as confirmed by mutation analysis, knockdown experiments and MS analysis.
Some of these mutations are recorded in MITOMAP (http://www.mitomap.org/MITOMAP) as being related to some diseases, although none of them are labelled as "confirmed" pathogenic mutations.
Surprisingly, we found a very strong correlation as confirmed by several mutations in the sequence predicted to influence the stability of the RNA.
ISs can be viewed as mutator genes whose prevalence increases in bacterial populations over successive selective sweeps as they hitchhike with beneficial mutations that they produce [ 35, 70], as confirmed in experimental studies [ 24, 26].
Mutations or variants were confirmed in both directions as well as confirmed by a second independent PCR reaction.
In contrast, the polypoid tumor with BRAF mutation was confirmed as traditional serrated adenoma.
In addition, the expression of each nodD gene corresponding to each nodD mutation was confirmed as null (Fig. 2).
Control samples for pyrosequencing constituted 11 PTC samples with BRAF T1799A mutation status confirmed by Sanger sequencing as previously reported for ten of the cases by Sofiadis et al. (29), as well as three parathyroid adenomas.
Nevertheless, once mutation testing has confirmed as an effective criterion for test set evaluation (Andrews et al. 2005) we consider the set of faults modeled by its mutation operators a good starting point for FindBugs bug kind prioritization.
