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However, despite this milestone, donors with this mutation are still far too rare and limited to European populations.

We have recently reported that those testing negative for a family BRCA mutation are still at 3-fold relative risk of breast cancer [ 13].

Polymorphism at microsatellite loci occurs through additions and deletions of motifs in the repeat array, but the detailed dynamics of microsatellite mutation are still not fully understood (Buschiazzo and Gemmell 2006).

The accuracy of the cellular systems recognizing incorrect structures and their ability to discriminate between transiently misfolded wild type chains and those permanently changed by mutation are still insufficiently known.

It is noteworthy that cells expressing the N-terminal PD PINK1 mutation are still capable of producing the ΔN-PINK1 protein at levels comparable with PINK1-wt (Fig.  2C).

The presence of a serine at this position found in both cetacean species (fig. 4) was already described as naturally occurring in human but the physiological consequences for this specific mutation are still unknown (Harteveld et al. 2007).

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Whether any resistance to these Hsp90 inhibitor drugs could arise by Hsp90 mutation is still unknown.

Although genomic studies in the field of centrosome have been extensively carried out, with the lack of structural conformation, the proteomic analysis of pathological genetic mutation is still a challenging task.

However, its mechanism of leaf-color mutation is still far from fully being understood, and only a few related genes have been cloned up to now.

Although this forward genetic approach is powerful (e.g.[14]), identifying the causative mutation is still difficult and time consuming.

However, the L595S mutation was still present.

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