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Surprisingly, the resistance levels conferred by this mutation are low to moderate.
Therefore, it is difficult to identify HLA-associated variations if the allele frequencies and rates of mutation are low.
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In Central-Southern Italy the prevalence of p.C282Y mutation is low and in several patients the disease has different causes.
However, because this region is shared by one of the two unaffected individuals in generation II (Table 2), the likelihood that this region contains the mutation is low.
The frequency of ace1 R mutation was low even in carbamate resistant mosquitoes.
We detected somatic mutations in the polypyrimidine tract within the splice-acceptor site of intron 8, although the frequency of mutation was low.
In autosomal dominant disorders, the allele frequency for the mutation is low, thus homozygous individuals are very rare, with the exception of highly inbred populations.
Although the frequency of this mutation was low, it was more prevalent in subgroups of higher-grade breast tumors and those with mixed lobular/ductal histology.
As the probability of recombination or mutation is low, the number of these events follows a Poisson distribution (Sawyer and Hartl 1992).
This study showed that the overall burden of somatic mutation is low, especially in fusion-positive tumours (Shern et al, 2014).
For such a model to apply, the rate of introduction of new mutations (2Nμ) must be small, i.e., the "pressure" of mutation is low, which explains why they sometimes are called "weak mutation" models [ 44].
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