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In the context of evolutionary optimization, evolutionary operators, including crossover and mutation, are indispensable for solving a problem.
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Thus, Notch1 mutations, being indispensable for the majority of clinical T-ALL, require additional mutations in order to drive the leukemogenic process.
These findings broaden the spectrum of ALS-causing mutations and are indispensable for designing optimal strategies of mutational analysis and genetic counseling of ALS for patients of Chinese origin.
Mutations are the basis of genetic variation and mutant populations are indispensable genetic resources in all organisms.
Mutations in these lrx genes induce growth phenotypes implying that LRX proteins are indispensable for proper plant development.
Both proteins are indispensable components of the smooth muscle cells contractile apparatus and mutations in the encoding genes may prevent proper contraction of the smooth muscle cells.
All are indispensable.
Ferries are indispensable for transportation.
"None of us are indispensable.
Which works are indispensable?
Both worlds are indispensable.
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