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The clinical similarities and differences of our three cases and the additional published cases with the same mutation are highlighted in Table 1.
Positions showing evidence of recurrent mutation are highlighted in bold print.
Similar(58)
The position of the mutation is highlighted with an arrow.
The A/G start-codon mutation is highlighted in green, insertions or deletions are in yellow, stop-codons in red and conserved sequences are colored in magenta.
The translated amino acids are shown for each sequence, and the XbaI restriction site resulting from the T to A point mutation is highlighted.
Since recurrent mutations are highlighted there, one can also visually inspect the tree for repeated combinations of mutations.
Changes were introduced by PCR with the following oligos (altered bases for either restriction sites and/or mutations are highlighted by underlining).
Novel mutations are highlighted in boldface.
Mutations are highlighted by the use of bold font.
In the mutein sequence, the mutations are highlighted in violet.
Mutations are highlighted by the use of a bold font.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com