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On the other hand, histone H3.3 substitution and mutation are found in several tumors such as bone tumors and glioblastoma (Kato et al., 2015).
A homozygous FBXO7 nonsense mutation (R498X) is present in an Italian family, while compound heterozygous mutations (IVS7+1G/T and a T22M mutation) are found in a Dutch family.
Because MDM2 overexpression and high frequencies of TP53 mutation are found in many tumor types, additional studies on other tumor types would be warranted.
Furthermore, even in the context of mutations in the breast cancer susceptibility genes BRCA1 and BRCA2, high rates of p53 mutation are found [ 5, 6].
Moreover, whereas 39% of the 524 genes induced by the orc2-1 mutareon are found in starvation-induced clusters, starvation-repressed clusters contain just 8% of these genes.
Even though no information on residues critical for protein function were used for model generation, all residues leading to a total loss of enzyme activity upon alanine mutation are found in close spatial proximity.
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The ΔF508 mutation was found in 48.7% of the alleles.
No mutation was found in any of the samples.
BRAF V600 mutation was found in 58% and NRAS Q61 mutation in 21% of all cases.
Prothrombin mutation was found in 8 patients.
The identical mutation was found in family DUK6975.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com