Sentence examples for mutation are enrolled from inspiring English sources
According to Dutch guidelines, women with a BRCA1 or BRCA2 mutation are enrolled in the surveillance-screening program from age 25 years.
Patients with Cystic Fibrosis homozygous for the ΔF508 CF gene mutation were enrolled from 44 sites (n = 808 patients) as previously published.
Of 1060 patients screened from 13 countries, 118 (11.1%) harbouring an EGFR mutation were enrolled from 8 September 2010 to 15 February 2012.
Sixty patients with advanced solid tumors, 22 of whom were carriers of a BRCA1 or BRCA2 mutation, were enrolled and treated.
In the second stage, only those who had EGFR mutations were enrolled and treated with gefitinib.
A total of 50 ovarian cancer patients with BRCA mutations were enrolled.
In the expansion cohort, only patients with BRCA mutations were enrolled and treated at a continuous dosing schedule.
Of 1060 screened patients with NSCLC (859 known mutation status; 118 positive, mutation frequency 14%), 106 with EGFR sensitising mutations were enrolled (female 70.8% adenocarcinoma 97.2% never-smoker 64.2%).
Recently this was clearly demonstrated in breast cancer, with the development of the poly(ADP-ribose) polymerase inhibitor olaparib in a landmark phase I trial, whereby patients with BRCA1 or BRCA2 mutations were enrolled [ 8].
LS mutation carriers are enrolled in lifelong colonoscopy surveillance with 2 3-year intervals [ 10], and we took advantage of the regular surveillance to obtain consecutive specimens.
