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Isolates harboring the TR34/L98H mutation are cross-resistant to multiple azoles (4, 15, 17 ).
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It is now clear that BCRP mutations have a high impact on the substrate specificity of this transporter and that cells harbouring these mutations are cross-resistant to a wider variety of chemotherapeutic agents (Assaraf, 2006).
These data indicate that docetaxel-resistant MCF-7TXT cells are cross-resistant to paclitaxel.
Cry1A resistant insects with a mutation in the ABCC2 gene were cross-resistant to Cry1Fa and they lacked binding of Cry1A proteins and Cry1Fa to BBMV [ 39].
The doxorubicin-resistant A2780ADR cells showed 18-fold resistance to doxorubicin and were cross-resistant to cisplatin and carboplatin.
It had been demonstrated previously that SP15 was cross-resistant to Cry2Aa [26].
Of these, 65% (22) were cross-resistant to voriconazole and 74% (25) were cross-resistant to posaconazole.
In addition, an ADM-resistant Chinese hamster cell line, 77A-177, was cross-resistant to mAMSA.
The cisplatin-resistant sublines were cross-resistant to carboplatin and doxorubicin.
Of the 34 itraconazole-resistant isolates we studied, 65% (22) were cross-resistant to voriconazole and 74% (25) were cross-resistant to posaconazole.
It has been shown that the heterozygous gatekeeper mutation FGFR3 V555M emerged as a mechanism of acquired resistance to the selective FGFR inhibitor AZ12908010 in KMS-11 myeloma cells, and the resistant cells were cross-resistant to other FGFR inhibitors, AZD4547 and PD173074 [ 17].
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