The genetic mutation appears to be rare.
The mutation appears to be associated with increased risk of early-onset type 2 diabetes.
However, the rate of somatic de novo mutation appears to vary and may be family specific [38].
The Tyr204 mutation appears to affect the dynamic properties, while the Glu230 mutation affects the surface electrostatic profile of the enzyme.
The mutation appears to be specific to unipolar depression; no one in a group of 60 patients with manic depression, or bipolar disease, had it.
The mutation appears to be about ten generations (or a couple hundred years) old, whereas the oldest oral historical records of kuru only go back to the early 20th century.
It is, however, notable that the penetrance of the rsw4 mutation appears to vary among tissues.
Therefore, the rsw4 mutation appears to have a relatively weak overall effect on female gametophyte development.
Haplotype studies could help to determine if a specific mutation appears to occur on a common genetic background suggesting it has been inherited from a common ancestor, or if the shared mutation appears to have arisen independently multiple times.
The recently identified familial A2V mutation appears to preserve the first Cu2+ coordination sphere adopted by Cu2+/Aβ1 16.
The dcr mutation appears to represent a heritable model of vascular disease, with particularly severe pathology in the brain.
