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In this work, we study how the genetic code influences the fitness consequences of errors (loads) during mutation and translation.
Next, we study the effect of the different genetic codes on mutation and translation loads (see Methods).
However, it has not been addressed whether these variants differ from the standard genetic code as far as mutation and translation loads are concerned.
We show that the alternative codes may produce significantly different mutation and translation loads, particularly for genomes evolving with a rather large mutation bias.
However, alternative codes yield significantly different mutation and translation loads, in particular for genomes evolving under strong AT or GC mutation bias.
Our results show that the standard genetic code is generally preferable to naturally occurring variants, in the sense that it typically yields smaller mutation and translation loads.
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These represent the fitness loss due to mutations and translation errors.
The internal structure of the code is such that codons for related amino acids are adjacent in the code table resulting in a high (although not maximum) robustness of the code to mutations and translation errors as first noticed by Woese at a qualitative level [ 35, 82] and subsequently demonstrated quantitatively [ 87- 93].
Different genetic alterations of PTEN, including mutation, deletion, and translation suppression, could lead to aberrant EGFR pathway activation in GBM.
First mentioned in a diary exactly 1,000 years ago, in late 1008, it has over the centuries been subject to changes, adaptations, mutations and translations (not to mention being remade as a manga comic), all of which have helped it not just survive, but flourish.
Gene sequences were compared using Blast2 (http://blast.ncbi.nlm.nih.gov/Blast.cgi PAGE_TYPE=BlastSearch&BLAST_SPEC=blast2seq&LINK_LOC=align2seq) to obtain preliminary evidence regarding polymorphisms, mutations, and for translation of amino acids.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com