Sentence examples for mutation and subsequent from inspiring English sources

A process in the germinal centre by which B cells, following interaction and activation by follicular helper T cells, undergo immunoglobulin gene mutation and subsequent selection to generate B cells that express antibodies with increased affinity for the target antigen.

In chronic inflammatory diseases, for example ulcerative colitis, NO induces p53 stabilization and the initiation of DNA-damage response pathway, and also generation of p53 mutation and subsequent clonal selection of p53 mutant cells.

Gain of virulence was acquired through mutation and subsequent sequence exchanges between the two copies of Avr3c.

We suggest that microcolony-based growth can involve mutation and subsequent selection of mutants better adapted to grow on surfaces within crowded-cell environments.

In Duchenne muscular dystrophy, mutation and subsequent loss of Dystrophin destabilizes the other DGC members [4], which further leads to mechanical damage of the muscle cell membrane [5], [6].

A third possibility is that one allele harbors a mutation and subsequent LOH leads to a homozygous mutant.

AIDS Research and Therapy 4: 2. Background: The association between baseline drug resistance mutations and subsequent increase in viral failure has not been established for HIV-infected children.

The association between baseline drug resistance mutations and subsequent viral failure after 12 and 24 weeks of highly active antiretroviral therapy (HAART) was studied.

This can be reconciled with basic P. falciparum biology and epidemiology, and it is concluded that this pattern of extremely rare mutations and subsequent spread should be regarded as the most likely pattern of resistance to future antimalarials.

Azoxymethane, a rodent colon-specific carcinogen, induce DNA damage, and causes proto-oncogene K-ras point mutations and subsequent tumor formation if DNA damage is not repaired or removed.

Cancer risk management options through genetic testing for BRCA mutations and subsequent options for preventive surgery after testing positive can empower women and can also reduce morbidity and mortality[6].