Sentence examples for mutation and somatic from inspiring English sources

(A ) SPOP mutation and somatic BRCA1 gene alterations are mutually exclusive in primary prostate cancer.

Some agents inducing nondisjunction were also tested for the induction of point mutation and somatic crossing-over with these comparative analysis.

Interestingly, no cases were found in this study with a concurrent BRCA1-germline mutation and somatic BRCA1 promoter methylation (Table 3).

Genetically, HNPCC is characterised by germline mutation and somatic inactivation of the MMR genes (Liu et al, 1996; Lynch and Smyrk 1996; Lagerstedt Robinson et al, 2007).

Although the MGs within each population subsequently diversify by mutation and somatic recombination, most new MGs remain rare (Mascheretti et al. 2009), and many are eliminated seasonally as populations crash during the drier summer months (Prospero et al. 2007).

For the 98 CRCs, clinicopathologic data and evaluation of the DNA mismatch repair (MMR) system (using MSI analysis, immunohistochemistry (IHC) for MMR proteins, MMR germline mutation) and somatic BRAF mutation, had been performed previously [ 7], but only data from the 35 patients extensively studied by bisulfite genomic sequencing (BGS) are shown in Table  1.

Somatic mutations pre-validated by orthogonal technologies showed greater than 90% agreement with OncoScan® somatic mutation calls and somatic mutation concordance between sites averaged 97%.

Genomic mutations could be divided into germline mutations and somatic mutations.

In addition to germline variants, ' VarScan 2' is able to identify somatic mutations and somatic CNVs.

Cytosine methylation is a major contributor to the generation of disease-causing germline mutations and somatic mutations that cause cancer.

> -wrap-foot> We next examined known SNPs, known heterozygous mutations and somatic mosaic mutations of CAPS patients using MPS.