Sentence examples for mutation and risk from inspiring English sources

103, 104 Knowledge of one's mutation and risk status may also provide individuals with a sense of control and optimism.

The subjects were similar in most respects, with the exception of BRCA1/2 germline mutation and risk reduction therapy status.

22, 27 Hence, the offspring of an affected individual have a 50% probability of inheriting a mutation and risk for HCM.

The association between being carrier of the CHEK2 *1100delC mutation and risk of developing CBC was not statistically significant (RR=1.7; 95% CI=0.6 5.1) (Table 2).

In one of the first long-term studies of the psychological impact of carrying a BRCA1/2 mutation and risk-reducing surgery, women reported adverse consequences of RM (i.e., changes in sexual function and body image), although the majority of the women believed the benefits of decreased fear outweighed the negative outcomes they experienced [ 6].

The BOADICEA returns both predicted probabilities of carrying a BRCA1 or a BRCA2 mutation, and risks (by the age of up to 80 years) of developing breast or ovarian cancer for unaffected individuals, or the risk of contralateral breast cancer or ovarian cancer for those who have already developed a first breast cancer.

Our objective was to design a genotyping platform that would allow rapid genetic characterization of samples in the context of genetic mutations and risk factors associated with common neurodegenerative diseases.

Using mortality data from the relatives of 5,287 genotyped participants, of whom 120 carried a BRCA Ashkenazi Jewish founder mutation, in a community-based study of the Ashkenazi Jewish population in the Washington D.C area, we examined the association between the three Ashkenazi BRCA founder mutations and risk of overall and non-cancer mortality.

Finally, many mutations and risk factors associated with AD may not relate to Aβ metabolism.

I also examined potential associations between hereditary Fanconi anemia gene mutations and risk of hematologic cancers.

Following these research methods, both causative mutations and risk gene variants have been studied.