Sentence examples for mutation and resultant from inspiring English sources

The mutation and resultant adaptability of HIV-1 reverse transcriptase (RT) present a major challenge to the design of the effective antiviral strategies because many initially potent drugs lose efficacy over time.

This mutation and resultant differences in physicochemical properties imply that IPT activity could differ between the protein products of the ZmIPT2- T and ZmIPT2- C alleles.

Due to high prevalence of PTEN mutations and resultant activation of PI3K/AKT pathway, stabilization of HIF-1 α and activation of various target genes are frequently observed in endometrial cancer cells.

Several ALDH2 gene SNPs have been identified: among them, rs671 is a missense mutation, and the resultant mutant ALDH2*2 protein acts in a loss of function or dominant negative fashion17,18,19.

We look forward to descriptions of mutations and the resultant phenotype in other MMP genes.

Modest results from clinical trials with a variety of small-molecule FLT3 inhibitors suggest that improved understanding of FLT3 mutations and the resultant aberrations in signaling may be needed before we realize the full therapeutic potential of these agents.

The subjects in this study required cochlear implants, recapitulating what has previously been reported regarding the management of patients with mutations in ACTG1 and resultant NSHL [ 31].

In this review, these new findings are examined and placed in the context of the well-established association of clear cell RCC (ccRCC) with mutations in the von Hippel-Lindau (VHL) gene and resultant aberrant hypoxia inducible factor (HIF) signaling.

Proteins encoded by genes like MSX2, FGFR1-3, TWIST1, and EFNB1 control the intramembranous ossification of the skull, and mutation of these genes may lead to premature sutural and resultant craniosynostosis [ 3].

We demonstrated that the degradation of functional ZIP13 proteins by the VCP-linked ubiquitin proteasome pathway is the major pathogenic consequence of these mutations and that the resultant disturbance of intracellular Zn homeostasis can cause SCD-EDS (Fig  7).

The mutation deficiency alters G6PD enzyme function (2), exposing red blood cells to oxidative stress and resultant hemolysis in the presence of a stressor, such as primaquine (3, 4).