Sentence examples for mutation and protein from inspiring English sources
The method can be applied to any disease, mutation and protein, he said.
Oncology is the frontier of Precision Medicine and typically focus is on identification of gene fusions (e.g. crizotinib, an ALK inhibitor for ALK fusion proteins in lung cancer), mutations (as in the case of vemurafinib, a BRAF inhibitor for melanoma patients with the BRAF V600E mutation) and protein over- expression (e.g. Trastuzumab a HER2-targeted antibody for breast cancer).
Along with the progression of metaplasia, dysplasia and adenocarcinoma, p53 gene mutation and protein accumulation were frequently detected [ 5, 6].
Secondly, there is not a good correlation between DNA mutation and protein conformation or level of protein expression and thus between molecular biology and IHC.
20 The clinical role of p53 alteration, both mutation and protein accumulation, in breast cancer might differ according to subtype and treatment.
This preliminary finding of an association between FGFR3 mutation and protein expression requires confirmation in a larger cohort of tumors with FGFR3 mutations.
Human carcinoma SW13 cells [40] were transfected with APP695wt (wild type) and APP695swe (Swedish mutation) and proteins were isolated by homogenization in 0.1 M NaCl, 0.01 M Tris HCl, 0.001 M EDTA, pH 7.6, with proteinase inhibitors.
Bertherat, J. et al. Molecular and functional analysis of PRKAR1A and its locus (17q22 24) in sporadic adrenocortical tumors: 17q losses, somatic mutations, and protein kinase A expression and activity.
The NOEY2 gene mutations and protein expression in human breast cancers, adjacent breast tissues and breast benign lesions were analysed to explore the potential correlation between the mutation spectrum and breast cancer development and progression.
Gene mutations and protein expression can impact patient survival.
The coagulation work-up did not show any factor V Leiden or prothrombin gene G20210A mutations, and protein C, protein S, antithrombin III, factor VIII and homocysteine levels were normal.
