Sentence examples for mutation and poor from inspiring English sources
CD24 mRNA overexpression correlates strongly with p53 gene mutation and poor HCC differentiation [ 18].
Most of the false results obtained related to two samples with a p.V600K mutation and poor DNA quality.
A recent publication detailing the University of California, San Francisco experience has called into question the relationship between the BRAF mutation and poor clinicopathologic factors.
This observation is consistent with our previous report (Smith et al, 2002), and associations between K-Ras mutation and poorer prognosis and time to relapse (Andreyev et al, 1998; Conlin et al, 2005).
PIK3CA mutations were significantly associated with poorer survival in the paclitaxel plus placebo population (P = 0.018, data not shown), whereas no statistically significant association between PIK3CA mutation and poorer survival was observed in the lapatinib plus paclitaxel population (P = 0.056, data not shown).
Mesothelin overexpression in lung adenocarcinomas correlates with the presence of activating KRAS mutations and poor prognosis.
However, the association between KRAS mutational status and prognosis is controversial for patients with metastatic CRC that have not been treated with anti-EGFR antibodies, with some studies reporting a link between KRAS mutations and poor prognosis [15] and some reporting no association [12].
Additional studies have confirmed the association of KRAS mutations and poor prognosis [ 30, 32, 36- 38].
Interestingly, associations have been made between D310 mutations and poor disease-free survival, a late onset age, and estrogen and progesterone-negative breast cancers (Tseng et al, 2006).
The good predictive value of EGFR mutations and poor predictive value of KRAS mutations with regard to EGFR TKI treatment was not reflected in terms of prognosis in our patient cohort.
Interestingly, we have observed a correlation between R249S mutations and poor tumour differentiation (p=0.05; table 3); tumours with R249S mutations were also more frequently developed in non-cirrhotic liver (p=0.02) in contrast to other HBV-infected HCC.
