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The growing amount of mutation and polymorphism data being generated has created a need for computational tools to systematically analyze large sets of mutations and filter them for those that have the greatest potential functional impact.
Such exceptions are increasing and show the need to redefine the terms mutation and polymorphism.
Mutation and polymorphism of cancer-associated genes have been found to predict tumor formation and prognosis.
The distinction between mutation and polymorphism on the basis of their disease-causing capacity is further complicated.
The ongoing debate among scientists to resolve the nomenclature mutation and polymorphism is a step in the right direction.
In the era of advanced DNA sequencing tools and personal genomics, these earlier definitions of mutation and polymorphism are antiquated.
Similar(38)
However, phenomena including gene loss, differing evolutionary rates, convergence, selection, mutation and polymorphisms plague all these methods to various extents [33].
Mutations and polymorphism in Wnt10b, Dkk1, Dkk2, Sfrp1, Sost, Lrp6, and Gsk3β affect osteoblast function and therefore bone formation and bone mass [24] [30].
Pages 11 and 12, words "mutations" and "polymorphism" were used by Bakker et al. (2008).
This may reflect the phenotype of cells as well as differences in p53 mutations and polymorphism [ 16].
Overall, five sequence alterations, including both mutations and polymorphism, were found in the abovementioned spots in the 12 samples from these patients.
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