Sentence examples for mutation and lower from inspiring English sources

We also found a trend toward differences in the p53 exons in which mutations occurred, with higher frequency of exon 5 mutation and lower frequency of exon 6 mutation in Egyptian tumors.

The fact that the haplotype of the RETR114H patients is longer than that of the other non-mutant patients is in line with the "young" age of the mutation and lower recombination across this haplotype.

Several studies have shown a correlation between genetic aberrations, i.e. a p53 mutation, and lower response rates to chemotherapy and shorter overall survival times [ 39- 42].

Overall, the frequency of low-level mitochondrial DNA heteroplasmy (<1%) in SPG7 patients mutations was similar to control subjects, aged controls, patients with OPA1 mutation and lower than POLG patients (Fig. 9).

Loss-of-function DNASE1 mutations and lowered DNASE1 expression in diseased kidneys of both individuals with SLE and lupus-prone mice have been described (Fenton et al., 2009; Martinez-Valle et al., 2010; Napirei et al., 2000; Seredkina et al., 2009; Tsukumo and Yasutomo, 2004; Zykova et al., 2010).

We found that BCNS individuals with low-tumor burden demonstrated significantly fewer UV signature somatic mutations and lower overall somatic mutational load compared to BCNS individuals with high-burden, supporting a role of UV exposure in driving BCC development in BCNS individuals.

We thus restrict the model to parameter regimes with lower mutation rates and lower mutation effect variances.

Interestingly, we found fewer adaptive mutations and lower levels of CI in the harsh treatment where the extinction probabilities of beneficial mutations due to bottlenecks were lower.

In theory, classifiers that predict more true somatic mutations should show higher concordance with the database of somatic mutations and lower concordance with the germline database.

Although the frequency of these deleterious mutations was different among populations, the ORs associated with breast cancer were consistent for the two null mutations and lower for the missense mutation.

The APC mutation and LOH frequencies were not significantly different from those found in the sporadic adenomas (Table 2); however, the AFAP and MAP tumours had significantly higher frequencies of truncating mutations and lower frequencies of LOH than the MCRA tumours (Table 2).